Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 16/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427774 | 0.88 | KCNH2 (0.67) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4423521 | 0.86 | KCNH2 (0.69) | KCNH2GRIN2B | |
| SCHEMBL4433626 | 0.84 | KCNH2 (0.60) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4432838 | 0.83 | KCNH2 (0.70) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4429035 | 0.79 | KCNH2 (0.50) | KCNH2 | |
| Hydrochloric Acid SCHEMBL4435531 | 0.78 | CYP11B1 (0.40) | GRIN2BRXRAGRIN1 | |
| SCHEMBL4428123 | 0.76 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL4427594 | 0.76 | KCNH2 (0.52) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4436261 | 0.76 | NCOA3 (0.50) | KCNH2 | |
| SCHEMBL4422220 | 0.76 | RXRA (0.46) | GRIN2BRXRAGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-B1 | IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | disclosed |