Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430222 | 0.81 | FFAR1 (0.44) | KMT2AMEN1ALDH1A1HTTLMNA | |
| SCHEMBL4433142 | 0.80 | SLC6A2 (0.55) | KMT2AMEN1ALDH1A1HTTLMNA | |
| SCHEMBL5947827 | 0.80 | KMT2A (0.65) | KMT2AMEN1ALDH1A1CYP19A1HTT | |
| Hydrochloric Acid SCHEMBL4441383 | 0.79 | SLC6A2 (0.54) | KMT2AMEN1ALDH1A1HTTLMNA | |
| SCHEMBL3736074 | 0.77 | CYP1A2 (0.44) | KMT2AMEN1ALDH1A1HTTMAPT | |
| SCHEMBL4440597 | 0.76 | SLC6A2 (0.42) | KMT2AMEN1CYP19A1MAPTBACE1 | |
| SCHEMBL4435726 | 0.75 | KMT2A (0.61) | KMT2AMEN1ALDH1A1CYP19A1HTT | |
| SCHEMBL10973267 | 0.75 | HRH1 (0.67) | KMT2AMEN1ALDH1A1HTTMITF | |
| SCHEMBL4441702 | 0.73 | CNR1 (0.48) | KMT2AMEN1ALDH1A1HTTMITF | |
| SCHEMBL4433971 | 0.73 | CNR1 (0.48) | KMT2AMEN1ALDH1A1HTTMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |