Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.48 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4441383 | 0.98 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2KCNK2 | |
| SCHEMBL5947827 | 0.87 | KMT2A (0.65) | MEN1KMT2AALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL4432893 | 0.86 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3KCNH2KCNK2 | |
| SCHEMBL4441835 | 0.84 | CACNA1A (0.48) | SLC6A4MEN1KMT2ABACE1CACNA1A | |
| SCHEMBL4434677 | 0.82 | CASR (0.45) | SLC6A2SLC6A4SLC6A3KCNH2KCNK2 | |
| SCHEMBL4432789 | 0.82 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2KCNK2 | |
| SCHEMBL4435726 | 0.82 | KMT2A (0.61) | MEN1KMT2AALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL5161949 | 0.82 | HRH1 (0.67) | SLC6A2SLC6A4SLC6A3KCNH2KCNK2 | |
| SCHEMBL10973267 | 0.82 | HRH1 (0.67) | SLC6A2SLC6A4MEN1KMT2AALDH1A1 | |
| SCHEMBL4440597 | 0.80 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2KCNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |