Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.54 |
| ▸ | CASR | P41180 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433950 | 1.00 | MTNR1A (0.54) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| Hydrochloric Acid SCHEMBL4430466 | 0.99 | MTNR1A (0.53) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| Hydrochloric Acid SCHEMBL4433740 | 0.99 | MTNR1A (0.53) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| SCHEMBL4435363 | 0.92 | CNR1 (0.54) | CASRKDM4ECNR1CNR2KMT2A | |
| SCHEMBL4434954 | 0.92 | CNR1 (0.54) | CASRKDM4ECNR1CNR2KMT2A | |
| SCHEMBL4430527 | 0.91 | KDM4E (0.45) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| SCHEMBL4435507 | 0.91 | KDM4E (0.45) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| SCHEMBL4440265 | 0.91 | KDM4E (0.45) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| SCHEMBL4431243 | 0.91 | KDM4E (0.45) | MTNR1AMTNR1BCASRKDM4ECNR1 | |
| SCHEMBL4434661 | 0.91 | KDM4E (0.45) | MTNR1AMTNR1BCASRKDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |