Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 7/20 | 0.58 |
| ▸ | DRD5 | P21918 | 6/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4438820 | 0.98 | DRD1 (0.57) | DRD1DRD5DRD2DRD3HRH3 | |
| SCHEMBL4057707 | 0.95 | DRD1 (0.52) | DRD1DRD5DRD2DRD3HRH3 | |
| Hydrochloric Acid SCHEMBL4563201 | 0.94 | DRD1 (0.53) | DRD1DRD5DRD2DRD3HRH3 | |
| SCHEMBL4563167 | 0.87 | DRD1 (0.42) | DRD1DRD5DRD2DRD3HRH3 | |
| SCHEMBL7286091 | 0.82 | HRH3 (0.56) | DRD1DRD5DRD2DRD3HRH3 | |
| SCHEMBL18034987 | 0.81 | DRD1 (0.61) | DRD1DRD5DRD2DRD3HRH3 | |
| SCHEMBL20119176 | 0.81 | DRD1 (0.51) | DRD1DRD5DRD2DRD3HRH3 | |
| SCHEMBL14340583 | 0.79 | DRD1 (0.88) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL29515933 | 0.79 | DRD1 (0.88) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL875632 | 0.79 | ALOX15 (0.57) | HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132193-B1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2132193-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | Boehringer Ingelheim International GmbH (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116881-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-02 | — | — | WO | disclosed |
| EP-1975165-A1 | Substituted pyrrolidinamides, their production and utilisation as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2008-10-01 | — | — | EP | disclosed |