Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696195 | 0.77 | CYP19A1 (0.49) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL1491082 | 0.75 | APLNR (0.50) | ALDH1A1KDM4ELMNAHPGDPOLB | |
| SCHEMBL16370865 | 0.72 | P2RX7 (0.41) | KMT2AALDH1A1KDM4EPOLBMAOA | |
| SCHEMBL12340483 | 0.71 | TAAR1 (0.62) | KMT2AALDH1A1MEN1ADRB2ADRA1A | |
| Hydrochloric Acid SCHEMBL1437235 | 0.70 | TAAR1 (0.61) | KMT2AALDH1A1MEN1ADRB2ADRA1A | |
| SCHEMBL1491063 | 0.69 | MAPT (0.44) | KMT2AALDH1A1MEN1KDM4ELMNA | |
| SCHEMBL9917312 | 0.69 | KMT2A (0.48) | KMT2AALDH1A1MEN1HPGDAPOBEC3A | |
| SCHEMBL174384 | 0.69 | KDM4E (0.62) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL13027374 | 0.68 | KMT2A (0.48) | KMT2AALDH1A1MEN1HPGDAPOBEC3A | |
| Hydrochloric Acid SCHEMBL29442137 | 0.68 | KDM4E (0.60) | ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |