Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323662 | 0.85 | MAPT (0.67) | MAPTRECQLALDH1A1GFERMAPK1 | |
| Hydrochloric Acid SCHEMBL5326598 | 0.84 | MAPT (0.66) | MAPTRECQLALDH1A1GFERMAPK1 | |
| SCHEMBL5483633 | 0.83 | MAPT (0.65) | MAPTRECQLALDH1A1MAPK1LMNA | |
| SCHEMBL4435995 | 0.82 | MAPT (0.70) | MAPTRECQLALDH1A1GFERMAPK1 | |
| SCHEMBL14376967 | 0.81 | MAPT (0.62) | MAPTRECQLALDH1A1GFERMAPK1 | |
| SCHEMBL12643176 | 0.81 | MAPT (0.74) | MAPTRECQLALDH1A1GFERMAPK1 | |
| SCHEMBL4438156 | 0.81 | MAPK1 (0.69) | MAPTALDH1A1MAPK1LMNAGAA | |
| Hydrochloric Acid SCHEMBL15819898 | 0.80 | MAPT (0.61) | MAPTRECQLALDH1A1GFERMAPK1 | |
| SCHEMBL6606591 | 0.79 | MAPT (0.61) | MAPTRECQLALDH1A1GFERMAPK1 | |
| SCHEMBL4436843 | 0.79 | MEN1 (0.70) | MAPTALDH1A1GFERMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |