Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054295 | 0.86 | NPC1 (0.58) | ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL19086568 | 0.84 | EPHX1 (0.59) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL6118209 | 0.83 | EPHX1 (0.78) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL9538408 | 0.79 | ALDH1A1 (0.50) | EPHX1ALDH1A1MEN1ALOX12KMT2A | |
| SCHEMBL8612464 | 0.79 | EPHX1 (0.77) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL5713527 | 0.79 | EPHX1 (1.00) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL8613625 | 0.77 | EPHX1 (0.76) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL18550720 | 0.77 | NPC1 (0.71) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL31741297 | 0.77 | NPC1 (0.71) | EPHX1MAPTALDH1A1MEN1ALOX12 | |
| SCHEMBL13454582 | 0.77 | CA1 (0.75) | EPHX1MAPTALDH1A1MEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200977-A2 | F1F0-ATPASE INHIBITORS AND RELATED METHODS | The Regents of the University of Michigan (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009036175-A2 | F1F0-ATPASE INHIBITORS AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-03-19 | — | — | WO | disclosed |