Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9311503 | 0.82 | EPHX1 (0.62) | ALDH1A1SMN1; SMN2LMNAEPHX1NPC1 | |
| SCHEMBL9537505 | 0.82 | SLC9A1 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11158773 | 0.80 | PLK1 (0.55) | ALDH1A1LMNAPLK1EPHX1NPC1 | |
| SCHEMBL4436756 | 0.79 | EPHX1 (0.65) | ALDH1A1PLK1EPHX1NPC1RAB9A | |
| SCHEMBL9311007 | 0.75 | EPHX1 (0.53) | ALDH1A1SMN1; SMN2PLK1EPHX1NPC1 | |
| SCHEMBL3047510 | 0.74 | EPHX1 (0.66) | ALDH1A1SMN1; SMN2LMNAEPHX1NPC1 | |
| SCHEMBL11258013 | 0.73 | EPHX1 (0.72) | ALDH1A1SMN1; SMN2LMNAEPHX1NPC1 | |
| SCHEMBL13454582 | 0.71 | CA1 (0.75) | ALDH1A1SMN1; SMN2LMNAPLK1EPHX1 | |
| SCHEMBL4439620 | 0.71 | CA1 (0.77) | ALDH1A1SMN1; SMN2LMNAPLK1EPHX1 | |
| SCHEMBL21480122 | 0.70 | KMT2A (0.57) | ALDH1A1LMNANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536151-A1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM. | BOOTS CO PLC (GB) | 1993-04-14 | — | — | EP | disclosed |