Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | PIP4K2C | Q8TBX8 | 3/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438464 | 0.88 | JAK2 (0.34) | JAK2PTK2SRCABL1JAK3 | |
| SCHEMBL12703912 | 0.85 | JAK2 (0.45) | JAK2PTK2JAK3CCNE1CDK2 | |
| SCHEMBL1591527 | 0.84 | JAK2 (0.37) | JAK2PTK2SRCABL1JAK3 | |
| SCHEMBL4444408 | 0.77 | AXL (0.36) | JAK2PTK2JAK3PIP4K2CPDE5A | |
| SCHEMBL1590827 | 0.75 | JAK2 (0.37) | JAK2PTK2PTGS2 | |
| SCHEMBL3590041 | 0.74 | CSNK1D (0.41) | JAK2PTK2SRCABL1 | |
| SCHEMBL3584532 | 0.73 | JAK2 (0.45) | JAK2PTK2CCNE1CDK2PIP4K2C | |
| SCHEMBL1590726 | 0.72 | CSNK1D (0.38) | SRCABL1JAK3CCNE2CCNE1 | |
| SCHEMBL1590587 | 0.72 | CSNK1D (0.51) | JAK2PTK2SRCABL1JAK3 | |
| SCHEMBL6470656 | 0.70 | CCNE2 (0.37) | CCNE2CCNE1CDK2KDM1APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | claimed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | claimed |