Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.34 |
| ▸ | NMT1 | P30419 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590653 | 0.87 | LMNA (0.40) | AXLEGFRBTKJAK2NMT1 | |
| SCHEMBL6015418 | 0.86 | FLT3 (0.37) | AXLEGFRBTKPDE5ANMT1 | |
| SCHEMBL3596341 | 0.85 | CSNK1D (0.40) | EGFRBTK | |
| SCHEMBL3597039 | 0.82 | SYK (0.34) | AXLJAK3NMT1GPR119SYK | |
| SCHEMBL6015423 | 0.79 | SRC (0.44) | — | |
| SCHEMBL4436776 | 0.77 | JAK2 (0.35) | JAK3PDE5AJAK2PTK2PIP4K2C | |
| SCHEMBL1590726 | 0.76 | CSNK1D (0.38) | JAK3LCKEGFRBTKPIP4K2C | |
| SCHEMBL1590587 | 0.76 | CSNK1D (0.51) | JAK3EGFRJAK2PTK2SYK | |
| SCHEMBL1590513 | 0.75 | CSNK1D (0.41) | JAK3LCKEGFRBTKGPR119 | |
| SCHEMBL1590512 | 0.75 | CSNK1D (0.41) | JAK3LCKEGFRBTKGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | disclosed |