SCHEMBL4436933

SCHEMBL4436933

COc1cc([N+](=O)[O-])ccc1-c1ccncc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.62
CYP11B1 P15538 4/20 0.62
CYP11B2 P19099 4/20 0.62
HTT P42858 2/20 0.55
RAF1 P04049 1/20 0.51
TDP1 Q9NUW8 2/20 0.50
PKM P14618 1/20 0.50
KMT2A Q03164 4/20 0.48
LMNA P02545 1/20 0.48
MEN1 O00255 2/20 0.47
PDE4D Q08499 1/20 0.46
PDE4B Q07343 1/20 0.46
AKR1C3 P42330 1/20 0.46
AKR1C2 P52895 1/20 0.46
POLB P06746 2/20 0.46
ALPL P05186 1/20 0.45
NPC1 O15118 1/20 0.45
PKN1 Q16512 1/20 0.45
PKN2 Q16513 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31061810 1.00 CYP19A1 (0.62) CYP19A1CYP11B1CYP11B2HTTRAF1
SCHEMBL7034422 0.88 TDP1 (0.54) CYP19A1CYP11B1CYP11B2HTTRAF1
SCHEMBL3185913 0.84 HTT (0.58) CYP19A1CYP11B1CYP11B2HTTTDP1
SCHEMBL4073859 0.84 CYP19A1 (0.69) CYP19A1CYP11B1CYP11B2HTTTDP1
SCHEMBL16370879 0.84 HTT (0.51) CYP19A1CYP11B1CYP11B2HTTTDP1
SCHEMBL1492729 0.83 KMT2A (0.50) CYP19A1CYP11B1CYP11B2HTTTDP1
SCHEMBL2184978 0.82 HTT (0.49) CYP19A1CYP11B1CYP11B2HTTTDP1
SCHEMBL16371403 0.82 HTT (0.56) CYP19A1CYP11B1CYP11B2HTTTDP1
SCHEMBL7632075 0.82 HTT (0.55) HTTTDP1PKMKMT2ALMNA
SCHEMBL11697350 0.82 HTT (0.55) CYP19A1CYP11B1CYP11B2HTTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195452-B2 N-(4-(oxazol-5-yl)phenyl) chromane-3-carboxamide derivatives and related compounds as stimulators of the production of retinal precursor cells for the treatment of neuroretinal diseases ENDOGENA THERAPEUTICS, INC. (US) 2025-01-14 US disclosed
EP-3902798-B1 N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS INC (US) 2023-12-20 EP disclosed
EP-3902798-B1 N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS INC (US) 2023-12-20 EP disclosed
US-20220089583-A1 N-(4-(OXAZOL-5-YL)PHENYL) CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2022-03-24 US disclosed
US-20220089547-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2022-03-24 US disclosed
US-20220089583-A1 N-(4-(OXAZOL-5-YL)PHENYL) CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2022-03-24 US disclosed
EP-3902606-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF NEURORETINAL DISEASES Endogena Therapeutics, Inc. (US) 2021-11-03 EP disclosed
EP-3902798-A1 N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES Endogena Therapeutics, Inc. (US) 2021-11-03 EP disclosed
CN-113301958-A Compounds for use as therapeutically active substances in the treatment and/or prevention of neuroretinal diseases 内生疗法公司 2021-08-24 CN disclosed
CN-113227086-A N- (4- (oxazol-5-yl) phenyl) chroman-3-carboxamide derivatives and related compounds as stimulators of production of retinal precursor cells for the treatment of neuroretinal diseases 内生疗法公司 2021-08-06 CN disclosed
US-20200207719-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT OF RETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 US disclosed
WO-2020140050-A1 N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 WO disclosed
WO-2020140043-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 WO disclosed
US-20200207749-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT OF RETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 US disclosed
US-20200207749-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT OF RETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 US disclosed
WO-2020140043-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 WO disclosed
US-20200207719-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT OF RETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 US disclosed
WO-2020140050-A1 N-(4-(OXAZOL-5-YL)PHENYL)CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES ENDOGENA THERAPEUTICS, INC. (US) 2020-07-02 WO disclosed
US-20090270450-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2009-10-29 US disclosed
WO-2004046118-A2 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2004-06-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089547-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF NEURORETINAL DISEASES ALDH1A2, NR2E3, BDNF CYP19A1 4211/4885CYP11B1 383/4885CYP11B2 328/4885
US-20200207749-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT OF RETINAL DISEASES ALDH1A2, NR2E3, ARRB1 CYP19A1 4754/4885CYP11B1 945/4885CYP11B2 764/4885
US-20200207719-A1 COMPOUNDS FOR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT OF RETINAL DISEASES ALDH1A2, NR2E3, PDE6D CYP19A1 4452/4885CYP11B1 464/4885CYP11B2 337/4885
US-12195452-B2 N-(4-(oxazol-5-yl)phenyl) chromane-3-carboxamide derivatives and related compounds as stimulators of the production of retinal precursor cells for the treatment of neuroretinal diseases NR2E3, GFRA2, ALDH1A2 CYP19A1 3982/4885CYP11B1 953/4885CYP11B2 539/4885
US-20220089583-A1 N-(4-(OXAZOL-5-YL)PHENYL) CHROMANE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS STIMULATORS OF THE PRODUCTION OF RETINAL PRECURSOR CELLS FOR THE TREATMENT OF NEURORETINAL DISEASES NR2E3, GFRA2, ALDH1A2 CYP19A1 3982/4885CYP11B1 953/4885CYP11B2 539/4885
US-20090270450-A1 CHEMICAL COMPOUNDS CSF1R, CSF3R, FLT3 CYP19A1 1835/4885CYP11B1 2601/4885CYP11B2 3130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.