Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433755 | 0.84 | LMNA (0.44) | ALDH1A1MAPTRAB9AGAAKDM4E | |
| SCHEMBL4436943 | 0.84 | HTT (0.43) | ALDH1A1MAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL4437052 | 0.81 | LMNA (0.41) | ALDH1A1MAPTRAB9AGAAKDM4E | |
| SCHEMBL4432749 | 0.80 | LMNA (0.40) | ALDH1A1MAPTRAB9AGAAKDM4E | |
| SCHEMBL16585132 | 0.77 | HSD17B10 (0.46) | ALDH1A1MAPTRAB9AGAAKDM4E | |
| SCHEMBL4437361 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTRAB9AGAAKDM4E | |
| SCHEMBL4443119 | 0.75 | LMNA (0.41) | ALDH1A1MAPTRAB9AGAAKDM4E | |
| SCHEMBL4172076 | 0.74 | NPSR1 (0.48) | ALDH1A1MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL4174787 | 0.73 | LMNA (0.41) | ALDH1A1GAAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL4174792 | 0.73 | LMNA (0.41) | ALDH1A1GAAKDM4ESMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3045458-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2016-07-20 | — | — | EP | disclosed |
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |