Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437068 | 0.94 | TDP1 (0.59) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL131373 | 0.93 | ALDH1A1 (0.53) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL10691467 | 0.86 | ESR1 (0.58) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL28865920 | 0.84 | ALDH1A1 (0.58) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL6757523 | 0.84 | KMT2A (0.45) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL28729189 | 0.83 | TDP1 (0.59) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL3148179 | 0.82 | TDP1 (0.67) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL4365824 | 0.82 | ALDH1A1 (0.57) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL8687409 | 0.81 | TDP1 (0.65) | TDP1MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL7789081 | 0.81 | TDP1 (0.59) | TDP1MEN1KMT2AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |