Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625836 | 0.93 | SLC6A4 (0.50) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL15862525 | 0.93 | SLC6A4 (0.54) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL3518646 | 0.92 | SLC6A4 (0.56) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL435398 | 0.89 | MAP3K12 (0.46) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL3135942 | 0.89 | TACR1 (0.46) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| Hydrochloric Acid SCHEMBL2270715 | 0.88 | TACR1 (0.45) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL14109292 | 0.87 | OPRL1 (0.45) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL14041008 | 0.87 | KMT2A (0.61) | KDM1AKMT2AOPRM1 | |
| SCHEMBL14894499 | 0.84 | KDM1A (0.45) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 | |
| SCHEMBL14894357 | 0.83 | KDM1A (0.51) | KDM1ASLC6A4SLC6A3SLC6A2BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | claimed |
| WO-2021078995-A1 | SELECTIVE POLYPEPTIDE SYNTHESIS STALLING ASSAY AND COMPOUND | UMC UTRECHT HOLDING B.V. (NL) | 2021-04-29 | — | — | WO | disclosed |
| EP-3811945-A1 | COMPOUNDS FOR TREATING AND PREVENTING GROWTH HORMONE RECEPTOR-DEPENDENT CONDITIONS | UMC Utrecht Holding B.V. (NL) | 2021-04-28 | — | — | EP | disclosed |
| EP-2530078-A1 | THIAZOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-12-05 | — | — | EP | disclosed |
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | VCAM1, ICAM1, SELE | KDM1A 3482/4885SLC6A4 2916/4885SLC6A3 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.