Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CCKAR | P32238 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437634 | 0.95 | CTSA (0.38) | ALDH1A1TSHRMAPTTP53SMN1; SMN2 | |
| SCHEMBL4181164 | 0.77 | CTSA (0.42) | TSHRCTSAKMT2A | |
| SCHEMBL4433276 | 0.76 | NPC1 (0.48) | ALDH1A1MAPTSMN1; SMN2GAAKMT2A | |
| SCHEMBL4443324 | 0.73 | CNR2 (0.36) | ALDH1A1TSHRMAPTKMT2ACNR2 | |
| SCHEMBL4178733 | 0.72 | CTSA (0.45) | TSHRCTSAKMT2A | |
| SCHEMBL27781354 | 0.67 | MBNL1 (0.40) | CTSACNR2 | |
| SCHEMBL12014807 | 0.67 | CTSA (0.45) | ALDH1A1SMN1; SMN2CTSA | |
| SCHEMBL4167601 | 0.66 | ELANE (0.39) | ALDH1A1MAPTSMN1; SMN2CTSAKMT2A | |
| SCHEMBL21543515 | 0.65 | KRAS (0.38) | MAPTDHODHNPC1RAB9A | |
| SCHEMBL31745253 | 0.65 | KRAS (0.38) | MAPTDHODHNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |