Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181164 | 0.77 | CTSA (0.42) | MEN1KMT2APIK3CD | |
| SCHEMBL4433320 | 0.77 | PIK3CD (0.43) | PIK3CD | |
| SCHEMBL4437843 | 0.76 | ALDH1A1 (0.38) | NPC1RAB9AKMT2ALMNAMAPT | |
| SCHEMBL4171072 | 0.75 | PIK3CD (0.42) | MEN1KMT2APIK3CDALDH1A1KDM4E | |
| SCHEMBL4175812 | 0.74 | PIK3CD (0.42) | NPC1KMT2APIK3CD | |
| SCHEMBL4174252 | 0.73 | PIK3CD (0.41) | PIK3CD | |
| SCHEMBL27781223 | 0.73 | PIK3CD (0.41) | NPC1MAPTPIK3CD | |
| SCHEMBL4178662 | 0.73 | PIK3CD (0.47) | MEN1KMT2AMAPTPIK3CDSMN1; SMN2 | |
| SCHEMBL4178733 | 0.72 | CTSA (0.45) | MEN1KMT2A | |
| SCHEMBL4437634 | 0.70 | CTSA (0.38) | KMT2AMAPTSMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |