Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13632359 | 0.87 | HSD17B10 (0.42) | KDM4EPKMHSD17B10L3MBTL1ALDH1A1 | |
| SCHEMBL23555007 | 0.85 | L3MBTL1 (0.56) | KDM4EGLAGAAPKMHSD17B10 | |
| SCHEMBL7383424 | 0.77 | CYP17A1 (0.33) | KDM4EHSD17B10L3MBTL1ALDH1A1 | |
| SCHEMBL10192197 | 0.77 | L3MBTL1 (0.50) | KDM4EGLAGAAPKMHSD17B10 | |
| SCHEMBL178417 | 0.76 | L3MBTL1 (0.49) | KDM4EGLAGAAPKMHSD17B10 | |
| SCHEMBL31030375 | 0.76 | L3MBTL1 (0.49) | KDM4EGLAGAAPKMHSD17B10 | |
| SCHEMBL16967062 | 0.76 | CNR1 (0.33) | KDM4EGLAL3MBTL1ALDH1A1 | |
| SCHEMBL19413530 | 0.75 | L3MBTL1 (0.49) | KDM4EGLAGAAPKMHSD17B10 | |
| SCHEMBL8347805 | 0.75 | L3MBTL1 (0.49) | KDM4EGLAGAAPKMHSD17B10 | |
| SCHEMBL5734356 | 0.75 | L3MBTL1 (0.36) | HSD17B10L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118089-A1 | INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008095821-A1 | INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-14 | — | — | WO | disclosed |