Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130118 | 0.93 | MEN1 (0.45) | HDAC1ABL1CTNNB1TCF7L2MEN1 | |
| SCHEMBL4132964 | 0.89 | HDAC1 (0.46) | HDAC1ABL1CTNNB1TCF7L2MEN1 | |
| SCHEMBL4138326 | 0.87 | HDAC1 (0.48) | HDAC1ABL1CTNNB1TCF7L2MAPT | |
| SCHEMBL4130124 | 0.86 | HDAC1 (0.44) | HDAC1ABL1CTNNB1TCF7L2MAPT | |
| SCHEMBL4138442 | 0.83 | HDAC1 (0.49) | HDAC1ABL1CTNNB1TCF7L2MAPT | |
| SCHEMBL4449009 | 0.83 | ABL1 (0.46) | HDAC1ABL1CTNNB1TCF7L2MAPT | |
| SCHEMBL4449995 | 0.82 | SMN1; SMN2 (0.47) | HDAC1ABL1KMT2AMAPT | |
| SCHEMBL27781589 | 0.80 | HDAC1 (0.51) | HDAC1MEN1KMT2AMAPT | |
| SCHEMBL4129999 | 0.80 | HDAC1 (0.48) | HDAC1ABL1CTNNB1TCF7L2MAPT | |
| SCHEMBL4132202 | 0.80 | BACE1 (0.47) | HDAC1ABL1CTNNB1TCF7L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134695-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | Exelixis, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008112913-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | EXELIXIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |