Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4142803 | 0.94 | MAPT (0.49) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4147051 | 0.90 | HIF1A (0.51) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4151375 | 0.88 | LRRK2 (0.59) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4139081 | 0.88 | HDAC1 (0.50) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4134801 | 0.87 | MAPT (0.48) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4144454 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4137724 | 0.84 | NPC1 (0.50) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL27963367 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTLMNAMAPK1GALR3 | |
| SCHEMBL4438971 | 0.82 | HDAC1 (0.43) | MAPTKMT2AABL1HDAC1 | |
| SCHEMBL27955756 | 0.81 | LMNA (0.49) | SMN1; SMN2MAPTLMNAMAPK1GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134695-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | Exelixis, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008112913-A1 | INHIBITORS OF THE HEDGEHOG PATHWAY | EXELIXIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |