Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436886 | 0.86 | SLC6A2 (0.35) | SLC6A2SLC6A3SLC6A4TACR1MEN1 | |
| SCHEMBL4051628 | 0.85 | SLC6A2 (0.38) | SLC6A2SLC6A3SLC6A4TACR1MEN1 | |
| SCHEMBL5214565 | 0.83 | SLC6A2 (0.37) | SLC6A2SLC6A3SLC6A4MEN1KMT2A | |
| SCHEMBL8437522 | 0.80 | SLC6A2 (0.38) | SLC6A2SLC6A3SLC6A4MEN1KMT2A | |
| SCHEMBL4444981 | 0.77 | SLC6A4 (0.40) | SLC6A2SLC6A3SLC6A4TACR1MEN1 | |
| SCHEMBL20141115 | 0.77 | SLC6A2 (0.48) | SLC6A2SLC6A3SLC6A4TACR1MEN1 | |
| SCHEMBL20141529 | 0.76 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4MEN1KMT2A | |
| SCHEMBL27799887 | 0.76 | SLC6A4 (0.39) | SLC6A2SLC6A3SLC6A4SSTR4 | |
| SCHEMBL4434907 | 0.76 | TACR1 (0.40) | SLC6A2SLC6A3SLC6A4TACR1 | |
| SCHEMBL7399910 | 0.76 | SLC6A2 (0.42) | SLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |