Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442462 | 0.86 | MEN1 (0.36) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4444981 | 0.85 | SLC6A4 (0.40) | TACR1SLC6A4SLC6A2SLC6A3KDM4E | |
| SCHEMBL4437622 | 0.84 | GAA (0.35) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4439262 | 0.84 | EPHX2 (0.39) | TACR1SLC6A4SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL4437504 | 0.83 | MAPT (0.45) | TACR1ALDH1A1 | |
| SCHEMBL5214565 | 0.82 | SLC6A2 (0.37) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4434449 | 0.81 | MAPK1 (0.40) | SLC6A4SLC6A2SLC6A3ALDH1A1HSD17B10 | |
| SCHEMBL4439470 | 0.80 | MEN1 (0.36) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7455407 | 0.78 | GPR119 (0.36) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7455396 | 0.78 | GPR119 (0.36) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |