Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.77 |
| ▸ | CA2 | P00918 | 5/20 | 0.77 |
| ▸ | CA9 | Q16790 | 4/20 | 0.77 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MIF | P14174 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3055643 | 0.88 | SMN1; SMN2 (0.72) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL27817425 | 0.86 | MEN1 (0.68) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13454582 | 0.85 | CA1 (0.75) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL9311007 | 0.81 | EPHX1 (0.53) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL28892777 | 0.81 | ALDH1A1 (0.82) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL16918559 | 0.80 | RAB9A (0.86) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL29971986 | 0.80 | RAB9A (0.86) | CA1CA2CA9NPC1RAB9A | |
| N-(Phenylcarbamothioyl)Benzamide SCHEMBL2341910 | 0.80 | EPHX1 (1.00) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL13453425 | 0.80 | CA1 (0.53) | CA1CA2CA9NPC1RAB9A | |
| SCHEMBL13453428 | 0.80 | CA1 (0.64) | CA1CA2CA9NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200977-A2 | F1F0-ATPASE INHIBITORS AND RELATED METHODS | The Regents of the University of Michigan (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009036175-A2 | F1F0-ATPASE INHIBITORS AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-03-19 | — | — | WO | disclosed |