Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.52 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 6/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434804 | 0.88 | BAZ2B (0.47) | BAZ2BBAZ2APARP1FOLH1AKR1C3 | |
| SCHEMBL27349513 | 0.87 | BAZ2B (0.50) | BAZ2BBAZ2APARP1FOLH1PDK2 | |
| SCHEMBL26365859 | 0.85 | FOLH1 (0.62) | FOLH1NPC1RAB9APTGER1PTGER4 | |
| SCHEMBL27525542 | 0.85 | BAZ2B (0.48) | BAZ2BBAZ2APARP1FOLH1PDK2 | |
| SCHEMBL4530811 | 0.81 | MKNK1 (0.53) | PARP1NPC1RAB9APLA2G2A | |
| SCHEMBL23479783 | 0.81 | HDAC8 (0.50) | FOLH1PDK2BRD4CREBBP | |
| SCHEMBL5307077 | 0.81 | PARP1 (0.56) | BAZ2BBAZ2APARP1PDK2NPC1 | |
| SCHEMBL11647426 | 0.80 | PTGER1 (0.53) | FOLH1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL3636122 | 0.80 | NR1H4 (0.56) | BAZ2BBAZ2APARP1PDK2NPC1 | |
| SCHEMBL4444932 | 0.80 | CSNK2A2 (0.46) | BAZ2BBAZ2APARP1PDK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |