Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530801 | 0.85 | MKNK1 (0.46) | L3MBTL1MEN1KMT2APARP1POLB | |
| SCHEMBL4530811 | 0.81 | MKNK1 (0.53) | L3MBTL1KMT2AFGFR1FGFR2FGFR4 | |
| SCHEMBL4439627 | 0.80 | BAZ2B (0.52) | BAZ2BBAZ2APDK2PARP1PLA2G2A | |
| SCHEMBL13575532 | 0.78 | MAPK1 (0.45) | KMT2APARP1POLBMAPTHSD17B10 | |
| SCHEMBL5006032 | 0.78 | MAPK1 (0.45) | KMT2APARP1TSHRHSD17B10MAPK1 | |
| SCHEMBL14235937 | 0.77 | PARP1 (0.50) | KMT2APARP1TSHRHSD17B10MAPK1 | |
| SCHEMBL27607184 | 0.77 | SMN1; SMN2 (0.44) | CSNK2A2CSNK2BCSNK2A1CSNK2A3L3MBTL1 | |
| SCHEMBL528444 | 0.77 | BCAT2 (0.55) | CSNK2A2CSNK2BCSNK2A1CSNK2A3MEN1 | |
| SCHEMBL7114095 | 0.75 | L3MBTL1 (0.59) | L3MBTL1MEN1KMT2APDK2PARP1 | |
| SCHEMBL27915078 | 0.74 | CHEK2 (0.49) | MEN1KMT2APARP1PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |