Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 6/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439627 | 0.88 | BAZ2B (0.52) | BAZ2BBAZ2APARP1FOLH1AKR1C3 | |
| SCHEMBL4444938 | 0.84 | MKNK1 (0.49) | PARP1FOLH1CREBBP | |
| SCHEMBL27349513 | 0.78 | BAZ2B (0.50) | BAZ2BBAZ2APARP1FOLH1PRKCI | |
| SCHEMBL3636122 | 0.78 | NR1H4 (0.56) | BAZ2BBAZ2APARP1PRKCIBRD4 | |
| Bicarbonate SCHEMBL28365018 | 0.77 | FOLH1 (0.50) | FOLH1RAB9A | |
| SCHEMBL27525542 | 0.77 | BAZ2B (0.48) | BAZ2BBAZ2APARP1FOLH1PRKCI | |
| Acetic Acid SCHEMBL28455812 | 0.76 | FOLH1 (0.49) | FOLH1 | |
| SCHEMBL5307077 | 0.75 | PARP1 (0.56) | BAZ2BBAZ2APARP1PRKCIFYN | |
| SCHEMBL473270 | 0.75 | PDCD1 (0.50) | FOLH1 | |
| SCHEMBL172981 | 0.74 | BCL2 (0.61) | PARP1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |