Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449523 | 0.85 | MAP2K4 (0.53) | MAPK1MAP2K4MYCWDR5CA12 | |
| SCHEMBL4444355 | 0.83 | CYP4F2 (0.38) | MAPK1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL4571230 | 0.80 | AR (0.47) | CA12CA1CA2CA9CA14 | |
| SCHEMBL28592006 | 0.78 | MAP2K4 (0.59) | MAPK1MAP2K4MYCWDR5CA12 | |
| SCHEMBL11144994 | 0.78 | MAP2K4 (0.52) | MAPK1MAP2K4CA12CA1CA2 | |
| SCHEMBL5767590 | 0.76 | ALDH1A1 (0.46) | MAPK1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL4009647 | 0.73 | MAPK1 (0.47) | MAPK1MAP2K4MYCWDR5CA12 | |
| SCHEMBL7346788 | 0.72 | CA1 (0.59) | CA12CA1CA2CA9CA14 | |
| SCHEMBL16061586 | 0.72 | ALDH1A1 (0.51) | MAPK1MAP2K4CA12CA1CA2 | |
| SCHEMBL20694706 | 0.72 | GRM6 (0.36) | CA12CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124937-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008099145-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |