Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440046 | 0.85 | MAPK1 (0.50) | MAP2K4MAPK1ALDH1A1LMNAKDM4E | |
| SCHEMBL7346788 | 0.72 | CA1 (0.59) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL16061586 | 0.72 | ALDH1A1 (0.51) | MAP2K4MAPK1ALDH1A1LMNAKDM4E | |
| SCHEMBL28592006 | 0.72 | MAP2K4 (0.59) | MAP2K4MAPK1ALDH1A1KDM4EMAPT | |
| SCHEMBL16061538 | 0.71 | HTT (0.50) | ALDH1A1LMNAKDM4EMAPTTP53 | |
| SCHEMBL11903949 | 0.70 | MAP2K4 (0.63) | MAP2K4MAPK1ALDH1A1KDM4ETP53 | |
| SCHEMBL16060753 | 0.70 | ALDH1A1 (0.45) | ALDH1A1LMNAKDM4EMAPTTP53 | |
| SCHEMBL22801611 | 0.69 | MAP2K4 (1.00) | MAP2K4MAPK1MAPTRHEBDHODH | |
| SCHEMBL4444355 | 0.69 | CYP4F2 (0.38) | MAPK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL10920925 | 0.69 | HSP90AA1 (0.44) | MAP2K4MAPK1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124937-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008099145-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |