Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441496 | 0.86 | FGFR1 (0.42) | FGFR1FGFR2FGFR4FGFR3ALDH1A1 | |
| SCHEMBL4441793 | 0.81 | FGFR1 (0.39) | FGFR1FGFR2FGFR4FGFR3ALDH1A1 | |
| SCHEMBL4441526 | 0.74 | FGFR4 (0.36) | FGFR1FGFR2FGFR4FGFR3ALDH1A1 | |
| SCHEMBL63963 | 0.73 | CLK2 (0.48) | FGFR1KDM4E | |
| SCHEMBL65154 | 0.73 | FGFR1 (0.50) | FGFR1FGFR2FGFR4FGFR3ALDH1A1 | |
| SCHEMBL64313 | 0.72 | NPC1 (0.53) | ALDH1A1MEN1KMT2AMAOBSMN1; SMN2 | |
| SCHEMBL28883606 | 0.72 | FGFR1 (0.47) | FGFR1FGFR2FGFR4FGFR3KMT2A | |
| SCHEMBL64245 | 0.71 | FGFR2 (0.39) | FGFR1FGFR2FGFR4FGFR3ALDH1A1 | |
| SCHEMBL64802 | 0.70 | NFKB1 (0.40) | FGFR4ALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL65041 | 0.70 | NPC1 (0.55) | FGFR1MEN1KMT2ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |