Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 4/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441793 | 0.79 | FGFR1 (0.39) | FGFR4FGFR1FGFR2FGFR3MAOA | |
| SCHEMBL4440134 | 0.74 | FGFR1 (0.36) | FGFR4FGFR1FGFR2FGFR3MAOA | |
| SCHEMBL4438519 | 0.73 | FGFR3 (0.45) | FGFR4FGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL64313 | 0.72 | NPC1 (0.53) | MAOBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL63963 | 0.69 | CLK2 (0.48) | FGFR1KDM4EHPGD | |
| SCHEMBL64317 | 0.68 | FGFR1 (0.64) | FGFR1FGFR2FGFR3ALDH1A1KMT2A | |
| SCHEMBL4441714 | 0.68 | KDM4E (0.36) | FGFR1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4440401 | 0.68 | MAPT (0.46) | FGFR4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL64802 | 0.68 | NFKB1 (0.40) | FGFR4ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL62670 | 0.67 | FGFR1 (0.52) | FGFR1FGFR2ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |