Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CBX7 | O95931 | 1/20 | 0.34 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17492955 | 0.79 | PIM1 (0.48) | PIM1ALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL15994159 | 0.79 | MEN1 (0.48) | PIM1ALDH1A1KDM4ENPC1MEN1 | |
| Hydrochloric Acid SCHEMBL1488003 | 0.78 | PIM1 (0.47) | PIM1ALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL6269009 | 0.78 | BCL2 (0.50) | LCK | |
| SCHEMBL27677355 | 0.70 | PTPRC (0.32) | PIM1 | |
| SCHEMBL15649811 | 0.67 | PIM1 (0.47) | PIM1ALDH1A1CYP1A2CYP2C19KDM4E | |
| SCHEMBL5820517 | 0.66 | PIM1 (0.36) | PIM1CYP1A2CYP2C19KDM4E | |
| Hydrochloric Acid SCHEMBL239434 | 0.66 | SMN1; SMN2 (0.45) | ALDH1A1HPGDCYP1A2CYP2C19KDM4E | |
| SCHEMBL28656542 | 0.64 | PDE4A (0.55) | PIM1ALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL1448153 | 0.63 | PTPN1 (0.69) | ALDH1A1HPGDHSD17B10KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237638-A1 | THERAPEUTIC, DIAGNOSTIC AND PROGNOSTIC METHODS FOR CANCER OF THE BLADDER | F. Hoffmann-La Roche AG (CH) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016105503-A1 | THERAPEUTIC, DIAGNOSTIC AND PROGNOSTIC METHODS FOR CANCER OF THE BLADDER | GENENTECH, INC. (US) | 2016-06-30 | — | — | WO | disclosed |
| EP-2118133-A2 | AMELIORATION OF CELLULAR STRESS RESPONSE | Genentech, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008109560-A2 | AMELIORATION OF CELLULAR STRESS RESPONSE | GENENTECH, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-1869070-A2 | HGF BETA CHAIN VARIANTS | GENENTECH, INC. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006113767-A2 | HGF BETA CHAIN VARIANTS | GENENTECH, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006026759-A9 | HUMANIZED ANTI-BETA7 ANTAGONISTS AND USES THEREFOR | GENENTECH INC (US) | 2006-05-18 | — | — | WO | disclosed |
| WO-2006015371-A9 | HUMANIZED ANTI-CMET ANTAGONISTS | GENENTECH INC (US) | 2006-03-30 | — | — | WO | disclosed |