Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1488003 | 0.98 | PIM1 (0.47) | PIM1MAPTALDH1A1LCKGLA | |
| SCHEMBL28656542 | 0.80 | PDE4A (0.55) | PIM1MAPTALDH1A1LCKGLA | |
| SCHEMBL4440142 | 0.79 | PIM1 (0.39) | PIM1MAPTALDH1A1LCKGLA | |
| SCHEMBL19478231 | 0.78 | MAPT (0.56) | MAPTALDH1A1LCKGLATHRB | |
| Hydrochloric Acid SCHEMBL2461009 | 0.77 | RAB9A (0.53) | PIM1MAPTALDH1A1LCKGLA | |
| SCHEMBL15649811 | 0.77 | PIM1 (0.47) | PIM1MAPTALDH1A1LCKGLA | |
| SCHEMBL10865211 | 0.75 | MAPT (0.67) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL1149730 | 0.74 | MAPT (0.66) | PIM1MAPTALDH1A1LCKGLA | |
| SCHEMBL8341400 | 0.73 | MAPT (0.69) | MAPTALDH1A1LCKGLATHRB | |
| SCHEMBL19461410 | 0.72 | MAPT (0.61) | PIM1MAPTALDH1A1LCKGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124419-A1 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-04-18 | — | — | US | disclosed |
| US-20230364084-A1 | METHODS FOR PREVENTING OR TREATING CONDITIONS RELATED TO PIKFYVE ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-11-16 | — | — | US | disclosed |
| US-20170119880-A1 | COMPOSITIONS AND METHODS FOR CHARACTERIZING, REGULATING, DIAGNOSING, AND TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-05-04 | — | — | US | disclosed |
| US-20160040163-A1 | DNAI FOR THE MODULATION OF GENES | PRONAI THERAPEUTICS INC (US) | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124419-A1 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | HSPA5, HSPA2, PSMG3 | PIM1 145/4885MAPT 1678/4885ALDH1A1 2525/4885 |
| US-20230364084-A1 | METHODS FOR PREVENTING OR TREATING CONDITIONS RELATED TO PIKFYVE ACTIVITY | PIKFYVE, PPME1, MTMR1 | PIM1 3240/4885MAPT 2421/4885ALDH1A1 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.