Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094147 | 0.76 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL3805475 | 0.76 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL5095939 | 0.76 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL20610605 | 0.73 | CYP11B1 (0.42) | MAPK8MAPK9MAPK10CYP11B1CYP11B2 | |
| SCHEMBL5094111 | 0.73 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK2LCK | |
| SCHEMBL3817520 | 0.71 | CYP11B1 (0.40) | MAPK8MAPK9MAPK10CYP11B1CYP11B2 | |
| SCHEMBL3820763 | 0.69 | CYP11B1 (0.39) | MAPK8MAPK9MAPK10CYP11B1CYP11B2 | |
| SCHEMBL1163018 | 0.67 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3809069 | 0.67 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL8193770 | 0.66 | MAPK8 (0.61) | MAPK8MAPK9MAPK10CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102194-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008068171-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |