Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436340 | 1.00 | P2RX7 (0.45) | P2RX7ROCK2EP300TRPV1CASR | |
| SCHEMBL4432774 | 0.93 | P2RX7 (0.49) | P2RX7ROCK2EP300TRPV1CASR | |
| SCHEMBL4433759 | 0.93 | P2RX7 (0.49) | P2RX7ROCK2EP300TRPV1CASR | |
| SCHEMBL4433732 | 0.92 | P2RX7 (0.41) | P2RX7ROCK2EP300TRPV1KDM4E | |
| SCHEMBL4436024 | 0.92 | P2RX7 (0.44) | P2RX7EP300TRPV1KDM4EALDH1A1 | |
| SCHEMBL4429672 | 0.90 | P2RX7 (0.38) | P2RX7EP300TRPV1 | |
| SCHEMBL4434631 | 0.90 | P2RX7 (0.38) | P2RX7EP300TRPV1 | |
| SCHEMBL4435812 | 0.88 | P2RX7 (0.38) | P2RX7EP300TRPV1 | |
| SCHEMBL4441783 | 0.88 | P2RX7 (0.38) | P2RX7EP300TRPV1 | |
| SCHEMBL4431161 | 0.88 | P2RX7 (0.46) | P2RX7EP300CASRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |