Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | CASR | P41180 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HAT1 | O14929 | 2/20 | 0.46 |
| ▸ | EP300 | Q09472 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428018 | 1.00 | CNR1 (0.57) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4441873 | 0.90 | KMT2A (0.67) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4435363 | 0.86 | CNR1 (0.54) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4431835 | 0.86 | CNR1 (0.54) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4431566 | 0.86 | CNR1 (0.54) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4434954 | 0.86 | CNR1 (0.54) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4435240 | 0.83 | CNR1 (0.50) | CNR1CNR2CASRALDH1A1EP300 | |
| SCHEMBL4436339 | 0.83 | CNR1 (0.50) | CNR1CNR2CASRALDH1A1EP300 | |
| SCHEMBL4438454 | 0.82 | ALDH1A1 (0.44) | CNR1CNR2KMT2ACASRALDH1A1 | |
| SCHEMBL4433947 | 0.82 | ALDH1A1 (0.44) | CNR1CNR2KMT2ACASRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |