Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 16/20 | 0.45 |
| ▸ | KDM6B | O15054 | 7/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KDM4A | O75164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025156 | 0.84 | SGMS2 (0.53) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL3605826 | 0.81 | TP53 (0.45) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL29102375 | 0.80 | KDM4C (0.45) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| Nitrous Acid SCHEMBL29102319 | 0.80 | KDM4E (0.49) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL21056814 | 0.79 | KDM4C (0.50) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL9165102 | 0.78 | KDM4C (0.47) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL1853295 | 0.75 | KDM4C (0.52) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL1555479 | 0.75 | L3MBTL1 (0.48) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL15288914 | 0.75 | GAA (0.52) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| Hydrochloric Acid SCHEMBL1554919 | 0.74 | L3MBTL1 (0.47) | KDM4CKDM6BKDM4DKDM4EKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057168-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |