Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 8/20 | 0.39 |
| ▸ | CDK8 | P49336 | 8/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 8/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279348 | 0.76 | KDM4E (0.78) | LRRK2KDM4EALDH1A1RXFP1POLB | |
| SCHEMBL15364318 | 0.70 | KDM4E (0.50) | LRRK2KDM4EALDH1A1RXFP1POLB | |
| SCHEMBL7452104 | 0.68 | NPSR1 (0.68) | LRRK2KDM4EALDH1A1RXFP1POLB | |
| SCHEMBL15365036 | 0.65 | KDM4E (0.41) | LRRK2KDM4EALDH1A1RXFP1POLB | |
| SCHEMBL15370235 | 0.64 | ALDH1A1 (0.46) | LRRK2KDM4EALDH1A1RXFP1POLB | |
| SCHEMBL1060812 | 0.64 | KDM4E (1.00) | LRRK2KDM4EALDH1A1RXFP1POLB | |
| SCHEMBL1858909 | 0.63 | S1PR1 (0.41) | KDM4EALDH1A1RXFP1POLBNPSR1 | |
| SCHEMBL1853292 | 0.60 | ALDH1A1 (0.37) | KDM4EALDH1A1RXFP1POLBNPSR1 | |
| SCHEMBL1857463 | 0.58 | NPSR1 (1.00) | KDM4EALDH1A1RXFP1POLBNPSR1 | |
| SCHEMBL19961831 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233977-B2 | Leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233977-B2 | Leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20130296317-A1 | LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME LLC | 2013-11-07 | — | — | US | disclosed |
| US-20130296317-A1 | LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME LLC | 2013-11-07 | — | — | US | disclosed |
| WO-2012058193-A1 | LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296317-A1 | LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | LRRK2, PARK7, AKT1 | LRRK2 1/4885KDM4E 3972/4885ALDH1A1 3085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.