Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | EIF4E | P06730 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3304229 | 0.88 | NR1H2 (0.40) | GPR119ROCK1NR1H2 | |
| SCHEMBL4429771 | 0.86 | ROCK1 (0.46) | GPR119ROCK1ADRB2ADRB1ADRB3 | |
| SCHEMBL3304235 | 0.83 | GPR119 (0.36) | GPR119ROCK1ADRB2ADRB1ADRB3 | |
| SCHEMBL3295839 | 0.80 | ADRB2 (0.45) | GPR119ADRB2ADRB1ADRB3 | |
| SCHEMBL3300949 | 0.76 | HRH3 (0.54) | ROCK1ADRB2ADRB1ADRB3EIF4E | |
| SCHEMBL3301776 | 0.75 | ROCK1 (0.43) | GPR119ROCK1 | |
| SCHEMBL13390147 | 0.70 | ADRB2 (0.40) | GPR119ADRB2ADRB1ADRB3 | |
| SCHEMBL3035321 | 0.70 | ROCK1 (0.47) | ROCK1ADRB2ADRB1ADRB3ATAD2 | |
| SCHEMBL13391670 | 0.69 | POLB (0.35) | GPR119ROCK1ADRB2ADRB1ADRB3 | |
| SCHEMBL3301780 | 0.69 | ROCK1 (0.42) | GPR119ROCK1EIF4EMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |
| EP-2121600-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099000-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |