SCHEMBL4442095

SCHEMBL4442095

Cc1ccc(F)c(Nc2n[nH]c3c2CN(C(=O)O)C3(C)C)n1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRKCB P05771 15/20 0.72
PAK4 O96013 5/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29483938 0.91 PRKCB (0.70) PRKCBPAK4
Ethyl Acetate SCHEMBL3327751 0.83 PRKCB (0.61) PRKCBPAK4
SCHEMBL3325739 0.82 PRKCB (1.00) PRKCB
SCHEMBL16627163 0.81 PRKCB (0.75) PRKCB
SCHEMBL3326156 0.80 PRKCB (1.00) PRKCB
SCHEMBL3323117 0.78 PRKCB (1.00) PRKCB
SCHEMBL3326631 0.78 PRKCB (1.00) PRKCBPAK4
SCHEMBL19200827 0.78 PRKCB (1.00) PRKCB
SCHEMBL22206298 0.77 PRKCB (0.75) PRKCBPAK4
SCHEMBL7013033 0.76 PRKCB (0.52) PRKCBPAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2118112-A1 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS Pfizer Inc. (US) 2009-11-18 EP disclosed
WO-2008096260-A1 3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS PFIZER INC. (US) 2008-08-14 WO disclosed