Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323117 | 1.00 | PRKCB (1.00) | PRKCB | |
| SCHEMBL3323872 | 0.87 | PRKCB (1.00) | PRKCB | |
| SCHEMBL3326156 | 0.86 | PRKCB (1.00) | PRKCB | |
| SCHEMBL3325739 | 0.84 | PRKCB (1.00) | PRKCB | |
| SCHEMBL3326784 | 0.84 | PRKCB (1.00) | PRKCB | |
| SCHEMBL16627163 | 0.83 | PRKCB (0.75) | PRKCB | |
| SCHEMBL3326631 | 0.83 | PRKCB (1.00) | PRKCB | |
| SCHEMBL598004 | 0.79 | PRKCB (1.00) | PRKCB | |
| SCHEMBL4442095 | 0.78 | PRKCB (0.72) | PRKCB | |
| SCHEMBL597616 | 0.78 | PRKCB (0.78) | PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089613-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2022-03-24 | — | — | US | disclosed |
| US-11220518-B2 | Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors | PFIZER INC. (US) | 2022-01-11 | — | — | US | disclosed |
| US-10316045-B2 | Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors | PFIZER INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20170217991-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217991-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, GPR119 | PRKCB 1116/4885 |
| US-10316045-B2 | Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors | PRKCB, PRKCA, PRKCE | PRKCB 1/4885 |
| US-11220518-B2 | Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors | JAK3, PRKCB, PRKCA | PRKCB 2/4885 |
| US-20220089613-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, GPR119 | PRKCB 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.