Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320830 | 0.83 | PIK3CD (0.48) | PIK3CDADRA1DADRA1AADRA1BDHODH | |
| SCHEMBL15320119 | 0.83 | ALDH1A1 (0.41) | ALDH1A1DHODHPDK1DHFRALKBH5 | |
| SCHEMBL16443651 | 0.78 | PIK3CD (0.44) | PIK3CDDHODHPIK3CADHFRALKBH5 | |
| SCHEMBL4184357 | 0.77 | PIK3CD (0.59) | PIK3CDDHODHPIK3CADHFRALKBH5 | |
| SCHEMBL4184351 | 0.77 | PIK3CD (0.59) | PIK3CDDHODHPIK3CADHFRALKBH5 | |
| SCHEMBL4442917 | 0.76 | PIK3CD (0.42) | PIK3CDADRA1DADRA1AADRA1BPIK3CA | |
| SCHEMBL15320238 | 0.75 | PIK3CD (0.58) | PIK3CDPIK3CA | |
| SCHEMBL19331525 | 0.75 | PIK3CD (0.69) | PIK3CDPIK3CA | |
| SCHEMBL16443649 | 0.75 | PIK3CD (0.49) | PIK3CDDHODHPIK3CAPDK1 | |
| SCHEMBL4442100 | 0.75 | PIK3CD (0.43) | PIK3CDDHODHPTGDR2PIK3CAPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834231-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013152150-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-10-10 | — | — | WO | disclosed |
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |