Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442401 | 1.00 | TGFBR1 (0.31) | TGFBR1HTR2AHTR2CSLC6A4ALK | |
| SCHEMBL4162696 | 0.82 | TGFBR1 (0.33) | TGFBR1SLC6A4 | |
| SCHEMBL4162702 | 0.82 | TGFBR1 (0.33) | TGFBR1SLC6A4 | |
| SCHEMBL2429710 | 0.79 | TACR1 (0.41) | SLC6A4 | |
| SCHEMBL2429709 | 0.79 | TACR1 (0.41) | SLC6A4 | |
| SCHEMBL12290816 | 0.74 | TACR1 (0.40) | SLC6A4 | |
| SCHEMBL2425778 | 0.74 | TP53 (0.38) | — | |
| SCHEMBL2425779 | 0.74 | TP53 (0.38) | — | |
| SCHEMBL2428697 | 0.72 | TACR1 (0.31) | SLC6A4 | |
| SCHEMBL2429202 | 0.70 | TACR1 (0.42) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009411-A1 | SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-15 | — | — | WO | disclosed |