Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002046 | 1.00 | CA12 (0.55) | CA12CA1CA2CA9LMNA | |
| Hydrochloric Acid SCHEMBL1285481 | 0.98 | LMNA (0.55) | CA12CA1CA2CA9LMNA | |
| SCHEMBL28150820 | 0.84 | CA1 (0.59) | CA12CA1CA2CA9ADRB2 | |
| SCHEMBL301661 | 0.83 | LMNA (0.70) | CA12CA1CA2CA9LMNA | |
| SCHEMBL27750065 | 0.81 | HPGD (0.56) | LMNAKDM4EADRB2ADRB1ADRB3 | |
| SCHEMBL6321975 | 0.80 | LMNA (0.51) | CA12CA1CA2CA9LMNA | |
| SCHEMBL8486918 | 0.80 | LMNA (0.63) | CA12CA1CA2CA9LMNA | |
| SCHEMBL12054668 | 0.80 | KEAP1 (0.75) | CA12CA1CA2CA9LMNA | |
| SCHEMBL4370199 | 0.79 | KEAP1 (0.52) | KEAP1ALDH1A1SMN1; SMN2KIF11 | |
| Hydrochloric Acid SCHEMBL1474929 | 0.79 | LMNA (0.53) | CA12CA1CA2CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
| EP-1857440-A1 | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same | Amorepacific Corporation (KR) | 2007-11-21 | — | — | EP | disclosed |