Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.34 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447736 | 0.73 | SIGMAR1 (0.38) | CYP2D6 | |
| SCHEMBL25096346 | 0.72 | CCR5 (0.32) | — | |
| SCHEMBL19146036 | 0.72 | CCR5 (0.32) | — | |
| SCHEMBL29256950 | 0.72 | CCR5 (0.32) | — | |
| SCHEMBL30217759 | 0.72 | CCR5 (0.32) | — | |
| SCHEMBL21155779 | 0.72 | CCR5 (0.32) | — | |
| Hydrochloric Acid SCHEMBL11625719 | 0.71 | — | — | |
| SCHEMBL7007764 | 0.70 | SLC6A2 (0.37) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6540338 | 0.70 | NPSR1 (0.37) | CYP2D6MC4R | |
| SCHEMBL1502251 | 0.70 | SLC6A4 (0.50) | CYP2D6SLC6A4GBA1SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041088-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | Amgen Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008002583-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | AMGEN INC. (US) | 2008-01-03 | — | — | WO | disclosed |