Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499182 | 0.86 | ELANE (0.41) | GPR119KMT2AATMMAPK1ABCB1 | |
| SCHEMBL6719409 | 0.86 | ELANE (0.41) | GPR119KMT2AATMMAPK1ABCB1 | |
| SCHEMBL6719418 | 0.84 | GPR119 (0.38) | GPR119HSD11B2KMT2AATMMAPK1 | |
| SCHEMBL3614066 | 0.83 | KEAP1 (0.41) | GPR119HSD11B2KMT2AATMKDM4E | |
| SCHEMBL3614064 | 0.83 | KEAP1 (0.41) | GPR119HSD11B2KMT2AATMKDM4E | |
| SCHEMBL13110173 | 0.83 | KEAP1 (0.41) | GPR119HSD11B2KMT2AATMKDM4E | |
| SCHEMBL7504062 | 0.82 | ABCB1 (0.42) | GPR119HSD11B2KMT2AMAPK1ABCB1 | |
| SCHEMBL16257111 | 0.81 | SPHK1 (0.45) | GPR119HSD11B2KMT2AKDM4EPKM | |
| SCHEMBL2078385 | 0.81 | HSD11B2 (0.42) | GPR119HSD11B2KDM4EPKMABCB1 | |
| SCHEMBL2080856 | 0.81 | HSD11B2 (0.42) | GPR119HSD11B2KDM4EPKMABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114906-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008092785-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |