Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 10/20 | 0.50 |
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553315 | 0.81 | IRAK4 (0.56) | IRAK4JAK3PTK2BKIF11PTK2 | |
| SCHEMBL1231905 | 0.80 | MAPK9 (0.57) | IRAK4JAK3PTK2BPTK2MAPK9 | |
| SCHEMBL1231948 | 0.79 | PTK2B (0.53) | IRAK4JAK3PTK2BKIF11PTK2 | |
| SCHEMBL1231919 | 0.79 | MAPK9 (0.56) | IRAK4JAK3PTK2BKIF11PTK2 | |
| SCHEMBL1232869 | 0.79 | MAPK9 (0.70) | IRAK4JAK3PTK2BPTK2MAPK9 | |
| SCHEMBL1231941 | 0.78 | MAPK9 (0.55) | IRAK4JAK3PTK2BPTK2MAPK9 | |
| SCHEMBL1230908 | 0.78 | PTK2 (0.58) | IRAK4JAK3PTK2BKIF11PTK2 | |
| SCHEMBL1231892 | 0.78 | MAPK9 (0.52) | IRAK4JAK3PTK2BKIF11PTK2 | |
| SCHEMBL1232833 | 0.77 | PTK2B (0.53) | IRAK4JAK3PTK2BKIF11PTK2 | |
| SCHEMBL1231772 | 0.77 | MAPK9 (0.56) | IRAK4JAK3PTK2BPTK2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134689-A2 | INHIBITORS OF FOCAL ADHESION KINASE | The Scripps Research Institute (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008115369-A2 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-25 | — | — | WO | disclosed |