Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 7/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.45 |
| ▸ | ULK1 | O75385 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232869 | 0.81 | MAPK9 (0.70) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL4444383 | 0.81 | IRAK4 (0.51) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1231948 | 0.79 | PTK2B (0.53) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1232318 | 0.79 | MAPK9 (0.59) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1231772 | 0.78 | MAPK9 (0.56) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1230908 | 0.77 | PTK2 (0.58) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1231919 | 0.77 | MAPK9 (0.56) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL5501767 | 0.77 | PTK2 (0.67) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1231941 | 0.76 | MAPK9 (0.55) | IRAK4JAK3PTK2BMAPK10MAPK9 | |
| SCHEMBL1231905 | 0.76 | MAPK9 (0.57) | IRAK4JAK3PTK2BMAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134689-A2 | INHIBITORS OF FOCAL ADHESION KINASE | The Scripps Research Institute (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008115369-A2 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-25 | — | — | WO | disclosed |