Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 6/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL1051689 | 0.90 | BBOX1 (0.42) | BBOX1FFAR3TSHRALDH1A1LMNA | |
| Bicarbonate SCHEMBL4444511 | 0.87 | BBOX1 (0.52) | BBOX1FFAR3TSHRALDH1A1LMNA | |
| Bicarbonate SCHEMBL4444508 | 0.83 | BBOX1 (0.54) | BBOX1FFAR3CA1HDAC3HDAC1 | |
| Oxalic Acid SCHEMBL1051691 | 0.82 | BBOX1 (0.48) | BBOX1FFAR3TSHRALDH1A1LMNA | |
| Bicarbonate SCHEMBL27990882 | 0.81 | TSHR (0.50) | BBOX1FFAR3TSHRALDH1A1LMNA | |
| SCHEMBL145746 | 0.80 | — | — | |
| Oxalic Acid SCHEMBL30381501 | 0.80 | BBOX1 (0.52) | BBOX1FFAR3CA1HDAC3HDAC1 | |
| Acetic Acid SCHEMBL5844598 | 0.80 | BBOX1 (0.52) | BBOX1FFAR3ALDH1A1CA1HDAC3 | |
| Oxalic Acid SCHEMBL1051688 | 0.80 | BBOX1 (0.52) | BBOX1FFAR3CA1HDAC3HDAC1 | |
| Bicarbonate SCHEMBL9003366 | 0.80 | BBOX1 (0.52) | BBOX1FFAR3CA1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839841-B1 | Anti-bacterial water absorbing agent and anti-bacterial water absorbent material | SANYO CHEMICAL IND LTD (JP) | 2009-05-06 | — | — | EP | disclosed |
| US-5981668-A | COMPRISING A WATER ABSORBING RESIN HAVING PENDANT ACID GROUPS, AT LEAST ONE ACID GROUP BEING IN THE FORM OF A QUATERNARY AMMONIUM SALT | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1999-11-09 | — | — | US | disclosed |
| EP-0839841-A2 | Anti-bacterial water absorbing agent and anti-bacterial water absorbent material | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-06 | — | — | EP | disclosed |