⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30711660 | 1.00 | — | — | |
| SCHEMBL35248 | 0.79 | — | — | |
| SCHEMBL34938 | 0.79 | — | — | |
| SCHEMBL29814771 | 0.79 | — | — | |
| SCHEMBL29626655 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL11719745 | 0.77 | NOS2 (0.95) | — | |
| SCHEMBL28572816 | 0.77 | NOS2 (0.95) | — | |
| SCHEMBL29101191 | 0.77 | NOS2 (0.95) | — | |
| SCHEMBL30482664 | 0.77 | NOS2 (0.95) | — | |
| Hydrochloric Acid SCHEMBL7421394 | 0.77 | NOS2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640708-A1 | HETEROCYCLE AMINES AND USES THEREOF | Ligand Pharmaceuticals Inc. (US) | 2013-09-25 | — | — | EP | claimed |
| WO-2012068546-A1 | HETEROCYCLE AMINES AND USES THEREOF | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | claimed |
| EP-2953457-B1 | ERK INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2020-04-08 | — | — | EP | disclosed |
| US-9980964-B2 | ERK inhibitors and uses thereof | CELGENE CAR LLC (BM) | 2018-05-29 | — | — | US | disclosed |
| US-9796700-B2 | ERK inhibitors and uses thereof | CELGENE CAR LLC (BM) | 2017-10-24 | — | — | US | disclosed |
| US-20170210729-A1 | ERK INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2017-07-27 | — | — | US | disclosed |
| US-20170137406-A1 | ERK INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2017-05-18 | — | — | US | disclosed |
| WO-2017075394-A1 | ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2 | EFFECTOR THERAPEUTICS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| US-9561228-B2 | ERK inhibitors and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-9504686-B2 | ERK inhibitors and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160082008-A1 | ERK INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2016-03-24 | — | — | US | disclosed |
| EP-2125807-B1 | IMIDAZO[1,2-A]PYRROLO[3,2-C]PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | UNIV LEUVEN KATH (BE) | 2011-08-03 | — | — | EP | disclosed |
| US-20100093781-A1 | IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | UNIVERSITE D'AUVERGNE CLERMONT 1 (FR) | 2010-04-15 | — | — | US | disclosed |
| US-20100093781-A1 | IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | UNIVERSITE D'AUVERGNE CLERMONT 1 (FR) | 2010-04-15 | — | — | US | disclosed |
| EP-2125737-A2 | PROCESS FOR THE SYNTHESIS OF 2,6-DIAMINOPYRIDINES FROM GLUTARIMIDINES | E. I. Du Pont de Nemours and Company (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008082500-A2 | PROCESS FOR THE SYNTHESIS OF 2,6-DIAMINOPYRIDINES FROM GLUTARIMIDINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008070937-A2 | IMIDAZO [1, 2-A] PYRROLO [3, 2-C] PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2008-06-19 | — | — | WO | disclosed |
| EP-1539757-A1 | SUBSTITUTED PYRROLOPYRIDINES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016609-A1 | SUBSTITUTED PYRROLOPYRIDINES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |
| US-4931487-A | Chain extenders for polyurethanes | DOW CHEMICAL COMPANY | 1990-06-05 | — | — | US | disclosed |