Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434283 | 0.98 | P2RX1 (0.45) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL6524494 | 0.98 | P2RX1 (0.45) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL12147169 | 0.95 | P2RX1 (0.47) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL12147197 | 0.95 | P2RX1 (0.47) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| Bromide SCHEMBL6522067 | 0.95 | P2RX1 (0.47) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL1372846 | 0.94 | P2RX1 (0.49) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL10723893 | 0.89 | P2RX1 (0.55) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL1372776 | 0.87 | SCN9A (0.44) | P2RX1P2RX3P2RX4P2RX7SCN9A | |
| SCHEMBL8552517 | 0.84 | SCN9A (0.54) | SCN9AMAPTMMP12ADAMTS5OPRL1 | |
| SCHEMBL3225659 | 0.83 | CHRM5 (0.48) | P2RX1P2RX3P2RX4P2RX7SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059545-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | FRESHPOINT HOLDINGS SA (CH) | 2011-03-10 | — | — | US | disclosed |
| EP-2121870-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | FRESHPOINT HOLDINGS SA (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008090045-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | FRESHPOINT HOLDINGS SA (CH) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059545-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | CCND3, CCNT1, SCO2 | P2RX1 2411/4885P2RX3 1143/4885P2RX4 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.